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How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 290-293 doi: 10.1007/s11684-010-0093-7

Abstract: The relevance of postmenopausal hormone therapy (HT) for breast cancer risk has been long debated, althoughThese unanswered questions include: whether HT has a positive impact on breast cancer; whether risks of therapywith unopposed estrogen and combined estrogen-progestin are different; and whether different types androutes of estrogen and progestogens, as well as the duration and cessation of HT use, have different

Keywords： breast cancer     postmenopausal hormone therapy     unopposed estrogen therapy     combined estrogen-progestin therapy    

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Photodynamic therapy combined with intravitreal injection of triamcinolone acetonide for choroidal neovascularization

YU Xiaobing, DAI Hong, LU Yingyi, LONG Li

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 405-409 doi: 10.1007/s11684-007-0079-2

Abstract: The aim of this research was to evaluate the efficacy and safety of photodynamic therapy (PDT) combinedPDT combined with intravitreal injection of TA was performed on 16 eyes of 16 patients with CNV diagnosedPDT combined with intravitreal injection of TA for CNV is safe and effective.

Keywords： intraocular pressure     fluorescein fundus     transient treatment     Transient intraocular     number    

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Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a

Li Ma, Bin Wang, Yuanxiong Long, Hanmin Li

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 191-202 doi: 10.1007/s11684-017-0512-0

Abstract: This systematic review with meta-analysis aimed to assess the effect of TCM combined with Western therapythe included studies, this review provided relevant data supporting the efficacy and safety of TCM combined

Keywords： traditional Chinese medicine     primary hepatic carcinoma     meta-analysis    

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MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus

Lingyan HOU, Yun LU, Ying LI, Li LI

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 1,   Pages 99-105 doi: 10.1007/s11783-013-0490-7

Abstract: biomarker for many diseases and toxicological effects in recent years, and some evidences showed that estrogen

Keywords： estrogen     microRNA (miRNA)     microarray     biomarker    

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Particle therapy for cancers: a new weapon in radiation therapy

Guo-Liang Jiang

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 165-172 doi: 10.1007/s11684-012-0196-4

Abstract: and intensity-modulated radiation therapy, proton therapy has yielded more promising outcomes in localCarbon therapy in Japan showed even more promising results than proton therapy.The non-invasive nature of particle therapy affords more patients with chances to receive and benefitParticle therapy is gradually getting attention from the oncology community.However, the cost of particle therapy facilities has limited the worldwide use of this technology.

Keywords： radiation therapy     particle therapy     proton     carbon     cancer    

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Passive antibody therapy in emerging infectious diseases

Frontiers of Medicine doi: 10.1007/s11684-023-1021-y

Abstract: In addition, the prospects of applying antibody therapy against VOCs was assessed, offering insights

Keywords： SARS-CoV-2     COVID-19     convalescent plasma     hyperimmunoglobulin     neutralizing monoclonal antibodies    

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mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 221-231 doi: 10.1007/s11684-020-0812-7

Abstract: rationale, the intriguing question is why cancers are insensitive or not responsive to mTOR-targeted cancer therapyERK, and Mnk/eIF4E survival signaling pathways that compromise the efficacy of rapalog-based cancer therapyThese new findings may also offer us the opportunity to rationally utilize mTOR inhibitors in cancer therapy

Keywords： mTOR     cancer therapy     resistance     GSK3     protein degradation     E3 ubiquitin ligase     PD-L1    

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Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 427-437 doi: 10.1007/s11684-018-0672-6

Abstract: Tyrosine kinase and γ-secretase inhibitors are primarily used in the targeted therapy of DF.Previous studies that focused on the mechanism, efficacy, and safety of targeted therapy for DF wereThe efficacy and safety of targeted therapy were compared with those of other systemic therapy optionsTargeted therapy does not provide considerable advantages in efficacy and safety over other medical treatmentsstudies are required to explore the mechanism, indications, and appropriate drug dosage of the targeted therapy

Keywords： targeted therapy     desmoid-type fibromatosis     tyrosine kinase inhibitor     γ-secretase inhibitor    

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Development of combined transitional pavement structure for urban tram track-road grade crossings

Frontiers of Structural and Civil Engineering   Pages 1199-1210 doi: 10.1007/s11709-023-0949-y

Abstract: The results show that PU elastic concrete and the proposed combined TRTP are applicable and functioned

Keywords： urban tram track     grade crossing     combined track-road transitional pavement     polyurethane elastic concrete    

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emissions: a comparative study of the feasibility of the hybrid renewable energy systems incorporating combined

Frontiers in Energy 2022, Volume 16, Issue 2,   Pages 336-356 doi: 10.1007/s11708-021-0748-x

Abstract: paper was to identify a grid connected renewable energy system coupled with natural gas reciprocating combined

Keywords： greenhouse gas control     low carbon target     grid connected     renewable fraction     fuel poverty     combined    

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Interaction and combined toxicity of microplastics and per- and polyfluoroalkyl substances in aquatic

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 10, doi: 10.1007/s11783-022-1571-2

Abstract:

● Adsorption of PFASs on MPs and its mechanisms are critically reviewed.

Keywords： Microplastics     Per- and Polyfluoroalkyl substances     Adsorption     Transport     Transformation    

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Hydroxyl radical-involved cancer therapy via Fenton reactions

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 3,   Pages 345-363 doi: 10.1007/s11705-021-2077-3

Abstract: Furthermore, the challenges and future developments of hydroxyl radical-involved cancer therapy are discussed

Keywords： hydroxyl radical     Fenton catalyst     hydrogen peroxide     cancer therapy    

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Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 1-10 doi: 10.1007/s11684-020-0741-5

Abstract: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a heterogeneous genetic profile. Chemotherapy exhibits substantial activity in a small subset of these patients. Drug resistance is inevitable. Major progress has been made in the genetic analysis of TNBC to identify novel targets and increase the precision of therapeutic intervention. Such progress has translated into major advances in treatment strategies, including modified chemotherapy approaches, immune checkpoint inhibitors, and targeted therapeutic drugs. All of these strategies have been evaluated in clinical trials. Nevertheless, patient selection remains a considerable challenge in clinical practice.

Keywords： triple-negative breast cancer     immunotherapy     targeted therapy    

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Translational medicine promising personalized therapy in oncology

Yi-Xin ZENG, Xiao-Shi ZHANG, Qiang LIU,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 351-355 doi: 10.1007/s11684-010-0320-2

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Silica-based nanoarchitecture for an optimal combination of photothermal and chemodynamic therapy functions

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12,   Pages 2144-2155 doi: 10.1007/s11705-023-2362-4

Abstract: This study introduces multifunctional silica nanoparticles that exhibit both high photothermal and chemodynamic therapeutic activities, in addition to luminescence. The activity of the silica nanoparticles is derived from their plasmonic properties, which are a result of infusing the silica nanoparticles with multiple Cu2–xS cores. This infusion process is facilitated by a recoating of the silica nanoparticles with a cationic surfactant. The key factors that enable the internal incorporation of the Cu2–xS cores and the external deposition of red-emitting carbon dots are identified. The Cu2–xS cores within the silica nanoparticles exhibit both self-boosting generation of reactive oxygen species and high photothermal conversion efficacy, which are essential for photothermal and chemodynamic activities. The silica nanoparticles’ small size (no more than 70 nm) and high colloidal stability are prerequisites for their cell internalization. The internalization of the red-emitting silica nanoparticles within cells is visualized using fluorescence microscopy techniques. The chemodynamic activity of the silica nanoparticles is associated with their dark cytotoxicity, and the mechanisms of cell death are evaluated using an apoptotic assay. The photothermal activity of the silica nanoparticles is demonstrated by significant cell death under near-infrared (1064 nm) irradiation.

Keywords： copper sulfide nanoparticles     chemodynamic therapy     photothermal therapy     carbon dots     silica nanoparticles    

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Title Author Date Type Operation

How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Journal Article

Photodynamic therapy combined with intravitreal injection of triamcinolone acetonide for choroidal neovascularization

YU Xiaobing, DAI Hong, LU Yingyi, LONG Li

Journal Article

Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a

Li Ma, Bin Wang, Yuanxiong Long, Hanmin Li

Journal Article

MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus

Lingyan HOU, Yun LU, Ying LI, Li LI

Journal Article

Particle therapy for cancers: a new weapon in radiation therapy

Guo-Liang Jiang

Journal Article

Passive antibody therapy in emerging infectious diseases

Journal Article

mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Journal Article

Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

Journal Article

Development of combined transitional pavement structure for urban tram track-road grade crossings

Journal Article

emissions: a comparative study of the feasibility of the hybrid renewable energy systems incorporating combined

Journal Article

Interaction and combined toxicity of microplastics and per- and polyfluoroalkyl substances in aquatic

Journal Article

Hydroxyl radical-involved cancer therapy via Fenton reactions

Journal Article

Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

Journal Article

Translational medicine promising personalized therapy in oncology

Yi-Xin ZENG, Xiao-Shi ZHANG, Qiang LIU,

Journal Article

Silica-based nanoarchitecture for an optimal combination of photothermal and chemodynamic therapy functions

Journal Article